[The inhalation administration of liposomes for the transport of broncholytic preparations in bronchial asthma].

Effectiveness of free and capsule phenoterol B2-agonist in experimental bronchial asthma has been assessed in vitro and in vivo in rats and rabbits using different liposomes: from egg lecithin, total phospholipids from pig or human lung. It was found that free phenoterol stabilizes mast cell (MC) condition, but has no antiinflammatory effect. Utilization of empty phospholipid vesicles brings both MC stabilization and decline of inflammation in the airways. In packing phenoterol in the liposomes antiinflammatory and membrane-stabilizing effects noticeably improved. It may be due to synergistic effects of the beta-agonist and phosphatidylcholine which is the base of liposome. The discussion covers mechanisms of high efficacy of homologous liposomes.