Nevzorova V A, Luk'ianov P A, Protopopova M Iu, Gel'tser B I
Vopr Kurortol Fizioter Lech Fiz Kult. 1996 Nov-Dec(6):12-4.
Effectiveness of free and capsule phenoterol B2-agonist in experimental bronchial asthma has been assessed in vitro and in vivo in rats and rabbits using different liposomes: from egg lecithin, total phospholipids from pig or human lung. It was found that free phenoterol stabilizes mast cell (MC) condition, but has no antiinflammatory effect. Utilization of empty phospholipid vesicles brings both MC stabilization and decline of inflammation in the airways. In packing phenoterol in the liposomes antiinflammatory and membrane-stabilizing effects noticeably improved. It may be due to synergistic effects of the beta-agonist and phosphatidylcholine which is the base of liposome. The discussion covers mechanisms of high efficacy of homologous liposomes.
已在体外以及在大鼠和兔子体内使用不同脂质体（来自鸡蛋卵磷脂、猪或人肺的总磷脂）评估了游离型和胶囊型酚丙喘宁（β2-激动剂）在实验性支气管哮喘中的有效性。研究发现，游离酚丙喘宁可稳定肥大细胞（MC）状态，但无抗炎作用。使用空的磷脂囊泡可实现MC稳定以及气道炎症减轻。将酚丙喘宁包裹在脂质体中时，抗炎和膜稳定作用显著改善。这可能归因于β-激动剂与作为脂质体基础的磷脂酰胆碱的协同作用。讨论内容涉及同源脂质体高效性的机制。
