Rohde T D, Blackshear P J, Varco R L, Buchwald H
Trans Am Soc Artif Intern Organs. 1977;23:13-6. doi: 10.1097/00002480-197700230-00004.
This study demonstrates the feasibility of ambulatory heparin therapy and its potential for successful treatment of refractory thromboembolic disease. The proven capability of the implantable infusion pump to provide long-term heparin infusion in ambulatory subjects suggests that it may have application in the delivery of other parenteral drugs as well.