Plaxe S C, Saltzstein S L
Department of Reproductive Medicine, University of California at San Diego, La Jolla 92103, USA.
Gynecol Oncol. 1997 Apr;65(1):8-12. doi: 10.1006/gyno.1996.4594.
To evaluate the impact of race/ethnicity on histology in endometrial cancer.
California Cancer Registry data on 11,674 white and 423 black women with endometrial cancer registered from 1988 to 1992 were used to compare the average annual age-adjusted incidence rate/100,000 women of low-risk (grades 1 and 2 endometrioid adenocarcinoma) and high-risk (grade >2 endometrioid carcinomas, papillary serous, clear cell, and adenosquamous histologies) lesions in black and white women.
Of the white patients, 9059 (78%) had low-risk and 2615 (22%) had high-risk lesions. Of the black patients, 236 (56%) had low-risk and 187 (44%) had high-risk lesions. The overall average annual age-adjusted incidence of endometrial cancer in white women is 20.1/100,000 and for black women is 9.4/100,000; however, the incidence of low-risk tumors is 15.9/100,000 in white women and only 5.3/100,000 in black women. The incidence of high-risk disease is identical in black and white women (4.2/100,000).
Black women in the general population have the same likelihood as white women of developing high-risk endometrial cancer. Black women have a significantly lower incidence of low-risk tumors compared to white women. The increased incidence of low-grade lesions in white women may be due to differences in socioeconomic factors or other factors yet to be identified.
评估种族/族裔对子宫内膜癌组织学的影响。
利用加利福尼亚癌症登记处1988年至1992年登记的11674名白人及423名黑人子宫内膜癌女性患者的数据，比较黑人和白人女性低风险（1级和2级子宫内膜样腺癌）和高风险（2级以上子宫内膜样癌、乳头状浆液性癌、透明细胞癌和腺鳞癌组织学类型）病变的年龄调整后平均年发病率/10万名女性。
白人患者中，9059例（78%）有低风险病变，2615例（22%）有高风险病变。黑人患者中，236例（56%）有低风险病变，187例（44%）有高风险病变。白人女性子宫内膜癌的总体年龄调整后平均年发病率为20.1/10万，黑人女性为9.4/10万；然而，白人女性低风险肿瘤的发病率为15.9/10万，黑人女性仅为5.3/10万。黑人和白人女性高风险疾病的发病率相同（4.2/10万）。
一般人群中的黑人女性患高风险子宫内膜癌的可能性与白人女性相同。与白人女性相比，黑人女性低风险肿瘤的发病率显著较低。白人女性低级别病变发病率的增加可能是由于社会经济因素或其他有待确定的因素的差异。
