Haq S A, Rahman M T, Hasan M, Khan A K
Department of Gastroenterology, Institute of Postgraduate Medicine and Research, Dhaka, Bangladesh.
Bangladesh Med Res Counc Bull. 1996 Aug;22(2):65-9.
The objective of the study was to assess the efficacy of sucralfate in promoting duodenal ulcer healing and to assess the value of some variables in predicting outcome of such therapy. Following variables were tested for predicting the outcome: age at onset, age at presentation, duration of symptoms, sex, periodicity, smoking, nocturnal pain, relief by food, relief by antacid, gastric stasis like symptoms, associated irritable bowel syndrome, site, size and number of ulcers and degree of deformity of bulb. Sixty patients with uncomplicated DU confirmed at endoscopy were treated with sucralfate one gram before three major meals and 1 g at bedtime for two months. Endoscopy was repeated at the end of the trial. There were four drop-outs. Complete, partial and no healing occurred in 45 (80.36)%, 3 (5.36%) and 8 (14.28%) subjects. Ulcer healing rate was higher in those without gross bulbar deformity (41/46) than in those with gross deformity (4/10), (Odd's ratio 12.3, 95% ci 1.98 to 78.44). Other variables were not found to be associated with ulcer healing.
本研究的目的是评估硫糖铝促进十二指肠溃疡愈合的疗效，并评估一些变量在预测该治疗结果中的价值。对以下变量进行了结果预测测试：发病年龄、就诊年龄、症状持续时间、性别、周期性、吸烟情况、夜间疼痛、食物缓解情况、抗酸剂缓解情况、胃潴留样症状、是否伴有肠易激综合征、溃疡部位、大小、数量以及球部畸形程度。60例经内镜确诊为单纯性十二指肠溃疡的患者，在三餐前及睡前服用1克硫糖铝，持续两个月。试验结束时重复进行内镜检查。有4例退出。45例（80.36%）患者溃疡完全愈合，3例（5.36%）部分愈合，8例（14.28%）未愈合。无明显球部畸形的患者溃疡愈合率（41/46）高于有明显畸形的患者（4/10），（优势比12.3，95%可信区间1.98至78.44）。未发现其他变量与溃疡愈合相关。
