Tsushima N, Kasai S, Koshino I, Jacobs G, Morinaga N, Washizu T, Kiraly R, Nosé Y
Trans Am Soc Artif Intern Organs. 1977;23:526-34. doi: 10.1097/00002480-197700230-00140.
A calf with a biolized TAH was maintained in reasonably good physiological condition for a major portion of a 145-day experiment as indicated by near normal growth rate and laboratory data. The mechanism for the high CVP and CBV at the beginning and end of the experiment were correlated with protein metabolism. No evidence of thromboembolism was found at autopsy and only modest congestion with minimal parenchymal damage was observed. The cardiac prosthesis itself was free of thrombus, although slight calcification was found on the valves and diaphragms. The pump performance, however, remained satisfactory. In addition, endothelialization appeared to be starting on a portion on the inside of the pump.
在一项为期145天的实验的大部分时间里，植入生物化全人工心脏（TAH）的小牛保持了相当良好的生理状态，接近正常的生长速度和实验室数据表明了这一点。实验开始和结束时中心静脉压（CVP）和脑血容量（CBV）升高的机制与蛋白质代谢有关。尸检未发现血栓栓塞迹象，仅观察到轻微充血和最小程度的实质损伤。心脏假体本身没有血栓，尽管在瓣膜和隔膜上发现了轻微钙化。然而，泵的性能仍然令人满意。此外，泵内部的一部分似乎开始出现内皮化。
