Nakano Y, Matsushita H
Department of Internal Medicine, Izumi Municipal Hospital, Osaka, Japan.
Nihon Kyobu Shikkan Gakkai Zasshi. 1997 Feb;35(2):220-6.
A 52-year-old man was admitted to our hospital with chief complaints of fever, general fatigue, and weight loss. A chest roentgenogram showed hyperinflation and many small nodular shadows in both lung fields. A chest CT scan showed centrilobular shadows distributed equally over all lung fields. Examination of a transbronchial lung biopsy specimen revealed a small non-caseating granuloma composed of a giant cell of Langhans type, epithelioid cells, and a few lymphocytes. There was a dark red eruption about 1 cm in diameter on the right forearm, which had been present for a few years, to the best of the patient's memory. Examination of a skin biopsy specimen revealed many non-caseating granulomas composed of epithelioid cells. Uveitis developed about 2 months after admission. Our diagnosis was sarcoidosis. Steroid therapy was started. The patient's symptoms rapidly disappeared and a chest roentgenogram showed remarkable improvement. We believe this was a very peculiar case of sarcoidosis: the patient had systemic symptoms only, and roentgenographic examinations showed hyperinflation and centrilobular shadows distributed over all lung fields.
一名52岁男性因发热、全身乏力和体重减轻为主诉入院。胸部X线片显示两肺野过度充气及许多小结节状阴影。胸部CT扫描显示小叶中心阴影均匀分布于所有肺野。经支气管肺活检标本检查发现一个小的非干酪样肉芽肿,由朗汉斯型巨细胞、上皮样细胞和少量淋巴细胞组成。据患者记忆,右前臂有一个直径约1cm的暗红色皮疹,已存在数年。皮肤活检标本检查发现许多由上皮样细胞组成的非干酪样肉芽肿。入院后约2个月出现葡萄膜炎。我们的诊断为结节病。开始使用类固醇治疗。患者症状迅速消失,胸部X线片显示明显改善。我们认为这是一例非常特殊的结节病病例:患者仅有全身症状,影像学检查显示过度充气及小叶中心阴影分布于所有肺野。