Praditpornsilpa K, Eiam-Ong S, Sitprija V
Department of Medicine, Faculty of Medicine, Chulalongkorn University Hospital, Bangkok, Thailand.
Singapore Med J. 1996 Dec;37(6):639-44.
Hepatitis A, B and C viruses are major causes of viral hepatitis in human. These infectious agents not only damage liver parenchyma but can also affect renal parenchyma. Hepatitis A virus could produce acute renal failure in a similar fashion to hepatorenal syndrome. Several lines of evidence have shown that chronic hepatitis B virus-infected patients could develop immune complex glomerulopathy. There are convincing data which incriminate hepatitis C virus as the proximate aetiology of certain forms of glomerulonephritis. In post-renal transplanted patients, hepatitis B and C virus could cause increased morbidity and mortality from chronic viral hepatitis. Whether renal transplantation should be performed, either as a donor or as a recipient, in subjects infected with hepatitis B or C virus, is still an issue of controversy.
甲型、乙型和丙型肝炎病毒是人类病毒性肝炎的主要病因。这些传染源不仅会损害肝实质，还会影响肾实质。甲型肝炎病毒可导致急性肾衰竭，其方式类似于肝肾综合征。多项证据表明，慢性乙型肝炎病毒感染患者可能会发生免疫复合物性肾小球病。有确凿数据证明丙型肝炎病毒是某些形式肾小球肾炎的直接病因。在肾移植术后患者中，乙型和丙型肝炎病毒可导致慢性病毒性肝炎的发病率和死亡率增加。对于感染了乙型或丙型肝炎病毒的患者，无论是作为供体还是受体，是否应该进行肾移植，仍然是一个有争议的问题。
