[垂体促性腺功能在诱导和抑制大鼠睾丸肿瘤发生中的作用]
[Gonadotropic functions of the hypophysis in the induction and suppression of the development of testicular tumors in rats].
作者信息
Dmitriev V N
出版信息
Vopr Onkol. 1977;23(9):52-5.
The work was carried out on 1379 mature rats. The content of gonadotropic hormones (TSH, LH, LBH) in the hypophysis was studied during the induction of specific testicular tumors. The development of germinogenic tumors (teratomas and serminomas) of testes was shown to proceed against the background of continuous enhancement of follicle-stimulating function of the hypophysis, while the occurrence of neoplasms from interstitial cells--against the background of persistently increased luteinizing function of the hypophysis. Suppression of FSH or LH production would prevent tumors development.
该研究以1379只成年大鼠为对象。在诱导特定睾丸肿瘤的过程中，对垂体中促性腺激素（促甲状腺激素、促黄体生成素、促卵泡激素）的含量进行了研究。结果显示，睾丸生殖细胞瘤（畸胎瘤和精原细胞瘤）的发生过程伴随着垂体促卵泡刺激功能的持续增强，而间质细胞瘤的发生则伴随着垂体促黄体生成功能的持续增强。抑制促卵泡激素或促黄体生成素的产生可预防肿瘤的发生。
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