Kawamura N, Furuta H, Tame A, Kobayashi I, Ariga T, Okano M, Sakiyama Y
Department of Pediatrics, Hokkaido University School of Medicine, Sapporo, Japan.
Int Arch Allergy Immunol. 1997 Apr;112(4):422-4. doi: 10.1159/000237491.
A case of X-linked autoimmune enteropathy was successfully treated with cyclosporine A (CsA) or tacrolimus (FK506) and developed extremely high serum levels of IgE during the immunosuppressive therapy. Serum IgE levels increased from 190 to 1,000-2,500 IU/ml with CsA therapy and as high as 80,000 IU/ml with subsequent FK506 therapy. Serum IgG2 and IgG4 levels were slightly elevated compared to serum IgE levels. Thereafter, serum IgE levels progressively decreased in parallel with a reduced dosage of FK506. Total serum IgG levels and peripheral eosinophil counts, however, showed no significant changes during the course. These observations suggest that both CsA and FK506, potent immunosuppressants, could paradoxically enhance some immune responses, possibly through the action of CsA-/FK506-resistant immune systems.
一名X连锁自身免疫性肠病患者成功接受了环孢素A（CsA）或他克莫司（FK506）治疗，在免疫抑制治疗期间血清IgE水平极高。CsA治疗期间血清IgE水平从190 IU/ml升至1000 - 2500 IU/ml，随后FK506治疗时高达80000 IU/ml。与血清IgE水平相比，血清IgG2和IgG4水平略有升高。此后，随着FK506剂量减少，血清IgE水平逐渐下降。然而，血清总IgG水平和外周嗜酸性粒细胞计数在病程中无显著变化。这些观察结果表明，强效免疫抑制剂CsA和FK506可能反常地增强某些免疫反应，可能是通过CsA/ FK506耐药免疫系统的作用。
