Characterization of clofazimine metabolites in humans by HPLC-electrospray mass spectrometry.
作者信息
Krishna D R, Mamidi R N, Hofmann U, Prabhakar C M
机构信息
Drug Metabolism Laboratory University College of Pharmaceutical Sciences, Kakatiya University, Warangal, India.
出版信息
Arzneimittelforschung. 1997 Mar;47(3):303-6.
PMID:9105550
Abstract
Clofazimine (CAS 2030-63-9) is an important drug used in the treatment of leprosy. Its important metabolites are investigated by thin layer chromatography (TLC), HPLC (diode array) and HPLC-electrospray mass spectrometry. The resulting analytical data, extraction, isolation and characterization methods are presented. Their applicability is described for human urine analysis.
摘要
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