采用高效液相色谱-电喷雾质谱法对人体内氯法齐明代谢产物进行表征。
Characterization of clofazimine metabolites in humans by HPLC-electrospray mass spectrometry.
作者信息
Krishna D R, Mamidi R N, Hofmann U, Prabhakar C M
机构信息
Drug Metabolism Laboratory University College of Pharmaceutical Sciences, Kakatiya University, Warangal, India.
出版信息
Arzneimittelforschung. 1997 Mar;47(3):303-6.
PMID:9105550
Abstract
Clofazimine (CAS 2030-63-9) is an important drug used in the treatment of leprosy. Its important metabolites are investigated by thin layer chromatography (TLC), HPLC (diode array) and HPLC-electrospray mass spectrometry. The resulting analytical data, extraction, isolation and characterization methods are presented. Their applicability is described for human urine analysis.
摘要
氯法齐明（CAS 2030-63-9）是一种用于治疗麻风病的重要药物。通过薄层色谱法（TLC）、高效液相色谱法（二极管阵列）和高效液相色谱-电喷雾质谱法对其重要代谢物进行了研究。给出了所得的分析数据、提取、分离和表征方法。描述了它们在人体尿液分析中的适用性。
Zotero 插件