Luciano R, Velardi F, Romagnoli C, Papacci P, De Stefano V, Tortorolo G
Division of Neonatology, Catholic University Medical School, Rome, Italy.
Childs Nerv Syst. 1997 Feb;13(2):73-6. doi: 10.1007/s003810050045.
Post-haemorrhagic hydrocephalus is assumed to result from obstruction of the cerebrospinal fluid (CSF) pathways by blood clots and subsequent chronic infiltration with collagen. The aim of this work was to evaluate the possibility of preventing permanent shunt dependence by enhancing the endoventricular fibrinolysis by means of an endoventricular streptokinase infusion in babies affected by posthaemorrhagic ventricular dilation. A case-control trial was carried out in 12 neonates affected by intraventricular haemorrhage and subsequent progressive ventriculomegaly. Six of them were treated with 20,000 U/day of streptokinase infused over 96 h through a percutaneous ventricular catheter. Our results show that the percentage of shunted babies was identical in treated and control patients despite the enhancement of endoventricular fibrinolysis obtained in all treated patients. On the basis of our results we do not recommend intraventricular streptokinase infusion for routine use in post-haemorrhagic ventricular dilatation.
出血后脑积水被认为是由血凝块阻塞脑脊液（CSF）通路以及随后胶原蛋白的慢性浸润所致。本研究的目的是评估在患有出血后心室扩张的婴儿中，通过脑室内注入链激酶增强脑室内纤维蛋白溶解来预防永久性分流依赖的可能性。对12例患有脑室内出血及随后进行性脑室扩大的新生儿进行了一项病例对照试验。其中6例通过经皮脑室导管在96小时内每天注入20000单位链激酶进行治疗。我们的结果显示，尽管所有接受治疗的患者脑室内纤维蛋白溶解得到增强，但治疗组和对照组中接受分流的婴儿百分比相同。基于我们的结果，我们不建议将脑室内注入链激酶常规用于出血后心室扩张。
