Iqbal J
Department of Craniofacial Surgery, Queen Elizabeth and Birmingham Children's Hospitals, UK.
Childs Nerv Syst. 1997 Feb;13(2):113-7. doi: 10.1007/s003810050056.
Osteopetrosis is a rare congenital disorder of bone resorption, which causes generalized hyperostosis. One of its many complications involves the skull base and progressive encroachment of the optic nerves within their canals, resulting in optic atrophy and blindness. Management of patients with deteriorating vision may include surgical decompression of the optic canals; their selection requires careful assessment by radiology, computed tomography, visual evoked potentials, electroretinography and possibly haemodynamic studies of the ophthalmic arteries. Postoperative changes can create difficulty in the interpretation of follow-up radiological investigations. In this study, transcranial Doppler sonography was used to assess the blood flow velocities in the ophthalmic arteries non-invasively. Pre- and postoperative studies of the Doppler parameters were done for each ophthalmic artery in a 5-month-old boy under standard physiological conditions. He presented with almost complete blindness and subsequently showed a good outcome following surgical intervention.
骨质石化症是一种罕见的先天性骨吸收障碍疾病，可导致全身性骨质增生。其众多并发症之一涉及颅底以及视神经在神经管内的逐渐受压，进而导致视神经萎缩和失明。对于视力恶化的患者，治疗可能包括对视神经管进行手术减压；患者的选择需要通过放射学、计算机断层扫描、视觉诱发电位、视网膜电图检查，以及可能的眼动脉血流动力学研究进行仔细评估。术后变化可能会给后续放射学检查结果的解读带来困难。在本研究中，经颅多普勒超声被用于无创评估眼动脉的血流速度。在标准生理条件下，对一名5个月大的男孩的每条眼动脉进行了术前和术后多普勒参数研究。该男孩几乎完全失明，手术干预后取得了良好效果。
