Sonntag H G, Nachtigall K
Zentralbl Bakteriol Orig A. 1977 Jul;238(3):310-9.
735 strains of staphylococci obtained from routine material were examined for biochemical characteristics claimed by BAIRD-PARKER (Bergey's Manual of Determinative Bacteriology, 1974) to be pathogenic features); the behaviour of the strains showing these properties was then compared to that of 12 antibiotics. Thereby, 237 of the 735 strains (32.2%, tab. 2) were positive for the combination of pathogenic features as proposed by BAIRD-PARKER (aerobic and anaerobic mannitol fermentation, beta-haemolysis, and positive coagulase reactivity), with approx. 30% of the Staphylococcus strains showing white pigmentation and 70% of them showing yellow pigmentation. The number of strains showing the combination of aerobic mannitol fermentation, beta-haemolysis, and positive coagulase reactivity was significantly higher: 341 out of 735 strains (46.4%, tab. 2). A comparison of the resistance to 12 antibiotics with the combination of pathogenic features of BAIRD-PARKER (Tab. 4) showed that he white Staphylococcus strains with this combination exhibited a significantly higher resistance to 6 of the tested antibiotics than the white Staphylococcus strains not showing these characteristics. Such a correlation between biochemical characteristics and resistance behaviour could not be demonstrated in the yellow Staphylococcus strains. The value of biochemical characteristics as features of pathogenicity and the resistance behaviour of staphylococcal strains to antibiotics in vitro for their pathogenic behaviour in vivo is discussed in relation to comparable results reported by other authors.
对从常规材料中获取的735株葡萄球菌进行了检测,以确定其是否具有拜尔德-帕克(Baird-Parker)所宣称的生化特征(《伯杰氏鉴定细菌学手册》,1974年,为致病特征);然后将表现出这些特性的菌株对12种抗生素的反应与其他菌株进行比较。由此,735株菌株中有237株(32.2%,表2)符合拜尔德-帕克提出的致病特征组合(需氧和厌氧甘露醇发酵、β-溶血和凝固酶反应阳性),其中约30%的葡萄球菌菌株呈现白色色素沉着,70%呈现黄色色素沉着。表现出需氧甘露醇发酵、β-溶血和凝固酶反应阳性组合的菌株数量显著更高:735株中有341株(46.4%,表2)。将对12种抗生素的耐药性与拜尔德-帕克的致病特征组合进行比较(表4),结果显示,具有这种组合的白色葡萄球菌菌株对6种测试抗生素的耐药性明显高于未表现出这些特征的白色葡萄球菌菌株。在黄色葡萄球菌菌株中未发现生化特征与耐药行为之间存在这种相关性。结合其他作者报告的可比结果,讨论了生化特征作为致病性特征的价值以及葡萄球菌菌株在体外对抗生素的耐药行为与其在体内致病行为的关系。