Carel J C, Lotton C, Bourgnères P
INSERM U342, Hôpital Saint Vincent de Paul, Paris, France.
Diabetes Metab. 1997 Mar;23 Suppl 2:29-33.
Current prediabetes screening relies mainly on immunologic markers. Genetic screening through HLA typing, which is used in families of affected patients, allows a stratification of risk levels according to the number and nature of alleles shared with the proband. Incomplete penetrance and the polygenic nature of susceptibility currently limit our ability to predict the disease with genetic markers. In addition, genetic factors can affect several aspects of the disease process, including insulin secretory capacity. This paper discusses the present and potential roles of genetic markers in prediabetes screening and briefly considers their use in the context of prevention trials.
目前的糖尿病前期筛查主要依赖免疫标志物。通过HLA分型进行的基因筛查用于患病患者的家族，可根据与先证者共享的等位基因数量和性质对风险水平进行分层。目前，不完全显性和易感性的多基因性质限制了我们使用基因标志物预测疾病的能力。此外，遗传因素可影响疾病过程的多个方面，包括胰岛素分泌能力。本文讨论了基因标志物在糖尿病前期筛查中的当前和潜在作用，并简要考虑了它们在预防试验中的应用。
