Peroxynitrite inhibits glutathione S-conjugate transport.
作者信息
Soszyński M, Bartosz G
机构信息
Department of Molecular Biophysics, University of Lódź, Poland.
出版信息
Biochim Biophys Acta. 1997 Apr 3;1325(1):135-41. doi: 10.1016/s0005-2736(96)00251-9.
PMID:9106491
Abstract
Peroxynitrite was demonstrated to inhibit the active efflux of glutathione S-conjugates (2,4-dinitrophenyl-S-glutathione and bimane-S-glutathione) from human erythrocytes and the erythrocyte membrane ATPase activity stimulated by glutathione S-conjugates. As the multidrug resistance-associated protein (MRP) is responsible for the transport of glutathione S-conjugates in mammalian cells, these results point to the possibility of the effect of peroxynitrite on the MRP function.
摘要
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