Soszyński M, Bartosz G
Department of Molecular Biophysics, University of Lódź, Poland.
Biochim Biophys Acta. 1997 Apr 3;1325(1):135-41. doi: 10.1016/s0005-2736(96)00251-9.
Peroxynitrite was demonstrated to inhibit the active efflux of glutathione S-conjugates (2,4-dinitrophenyl-S-glutathione and bimane-S-glutathione) from human erythrocytes and the erythrocyte membrane ATPase activity stimulated by glutathione S-conjugates. As the multidrug resistance-associated protein (MRP) is responsible for the transport of glutathione S-conjugates in mammalian cells, these results point to the possibility of the effect of peroxynitrite on the MRP function.
