Colamussi P, Trotta F, Ricci R, Cittanti C, Govoni M, Barbarella G, Giganti M, Bajocchi G, Uccelli L, Trevisan C, Piffanelli A
Department of Nuclear Medicine, St Anna Hospital and University, Ferrara, Italy.
Nucl Med Commun. 1997 Mar;18(3):269-73. doi: 10.1097/00006231-199703000-00012.
The diagnosis of central nervous system (CNS) involvement appears to be a major problem in systemic lupus erythematosus (SLE), especially when the clinical signs are non-specific or neuroimaging is unremarkable. Two SLE patients with mild neuropsychiatric manifestations were studied with magnetic resonance imaging (MRI), single photon emission tomography (SPET) and localized proton magnetic resonance spectroscopy (H-1 MRS). MRI was normal in both patients. SPET revealed areas of hypoperfusion in both patients. H-1 MRS demonstrated metabolic abnormalities in the regions corresponding to the hypoperfused areas. A correlation between H-1 MRS and SPET was noted: patients with mild neuropsychiatric SLE may have disturbances evident on SPET and H-1 MRS in the presence of normal anatomy on MRI, suggesting that CNS involvement in SLE has very strong physiological and neurometabolic components in individual patients.
中枢神经系统（CNS）受累的诊断似乎是系统性红斑狼疮（SLE）中的一个主要问题，尤其是当临床症状不具有特异性或神经影像学检查无明显异常时。对两名有轻度神经精神症状的SLE患者进行了磁共振成像（MRI）、单光子发射断层扫描（SPET）和局部质子磁共振波谱（H-1 MRS）研究。两名患者的MRI均正常。SPET显示两名患者均有灌注不足区域。H-1 MRS显示在与灌注不足区域相对应的区域存在代谢异常。注意到H-1 MRS与SPET之间存在相关性：轻度神经精神性SLE患者在MRI解剖结构正常的情况下，SPET和H-1 MRS可能会出现明显异常，这表明SLE患者的中枢神经系统受累在个体患者中具有非常强烈的生理和神经代谢成分。
