Conte R, Cirillo D, Ricci F, Tassi C, Tazzari P L
Servizio di Immunoematologia e Trasfusionale, Policlinico S. Orsola-Malpighi, Bologna, Italy.
Haematologica. 1997 Jan-Feb;82(1):73-4.
Patients affected by Glanzmann's thrombasthenia often require blood and platelet transfusions due to bleeding. They may develop antibodies against platelet antigens and become refractory to platelet transfusions. In this study we present our approach to platelet transfusion in a thrombasthenic patient with platelet antibodies directed against gpIIb/IIIa. We found that platelets from two HPA1b/b donors were weakly positive when matched with the patient's serum. The patient was submitted to dental surgery and platelets were transfused before and after surgery to prevent bleeding. The patient did not experience transfusion reaction and good platelet recovery was observed.
患有Glanzmann血小板无力症的患者常因出血而需要输血和血小板输注。他们可能会产生针对血小板抗原的抗体，并对血小板输注产生耐受。在本研究中，我们展示了针对一名患有针对gpIIb/IIIa的血小板抗体的血小板无力症患者的血小板输注方法。我们发现，来自两名HPA1b/b供体的血小板与患者血清匹配时呈弱阳性。该患者接受了牙科手术，术前和术后均输注了血小板以预防出血。患者未发生输血反应，且观察到血小板恢复良好。
