Howarth A T, Morgan D B, Payne R B
Am J Obstet Gynecol. 1977 Nov 1;129(5):499-502. doi: 10.1016/0002-9378(77)90086-2.
The distribution of the values for the daily urinary excretion of calcium during the last trimester of pregnancy was skewed toward high values in 1,034 women in Bradford, England. The logarithms of the values had a Gaussian distribution. The 95% range of this log-Gaussian distribution was 0.75 to 15.5 mmoles (30 to 620 mg.) per day. Nearly 20% of the values exceeded 8.75 mmoles (350 mg.) per day, which is the reported upper limit of the 95% range for nonpregnant women. Creatinine clearance is known to increase during pregnancy, and a prospective investigation in 112 pregnant Caucasian women in a hospital showed a highly significant correlation between calcium excretion and creatinine clearance. It is suggested that the increase in calcium excretion during pregnancy is due to the increase in glomerular filtration rate.
在英国布拉德福德的1034名女性中，孕期最后三个月每日尿钙排泄量的值呈高值偏态分布。这些值的对数呈高斯分布。这种对数高斯分布的95%范围是每天0.75至15.5毫摩尔（30至620毫克）。近20%的值超过每天8.75毫摩尔（350毫克），这是报道的非孕期女性95%范围的上限。已知孕期肌酐清除率会增加，对一家医院112名白人孕妇的前瞻性研究表明，钙排泄与肌酐清除率之间存在高度显著的相关性。有人认为孕期钙排泄增加是由于肾小球滤过率增加所致。
