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心脏手术后的胃肠道并发症。对1477例心脏手术患者的分析。

Gastrointestinal complications following cardiac surgery. An analysis of 1477 cardiac surgery patients.

作者信息

Perugini R A, Orr R K, Porter D, Dumas E M, Maini B S

机构信息

Department of Surgery, Fallon Healthcare System, Worcester, USA.

出版信息

Arch Surg. 1997 Apr;132(4):352-7. doi: 10.1001/archsurg.1997.01430280026003.

Abstract

OBJECTIVE

To determine preoperative and perioperative risk factors for gastrointestinal (GI) complications following cardiac surgery.

DESIGN

A database including records of patients who underwent cardiac surgery was reviewed, with univariate analysis of several variables thought to be relevant to GI complications. Using a risk-adjusted model, preoperative stratification was used to fit a logistic regression model including operative features.

SETTING AND PATIENTS

All patients undergoing cardiac surgery from January 1, 1991, to December 31, 1994, at a university-affiliated teaching hospital.

MAIN OUTCOME MEASURES

Incidence of GI complications, postoperative mortality, length of hospital stay, and relative risk of GI complications based on multivariate analyses.

RESULTS

Gastrointestinal complications occurred in 2.1% of patients and had an associated mortality of 19.4%; this was higher than the mortality in patients without GI complications (4.1%; P < .001). Length of hospital stay was significantly longer in patients with GI complications (43 vs 13.4 days; P < .001). In patients who underwent coronary artery bypass grafting only, cardiopulmonary bypass time was significantly longer in patients with GI complications (166 vs 138 minutes; P = .004). In patients who underwent valve replacement, bypass time was not associated with GI complications. Use of a left internal mammary artery graft was associated with a lower incidence of GI complications.

CONCLUSIONS

Patients who have GI complications after cardiac surgery have a higher mortality and a longer hospital stay. The use of a left internal mammary artery seems to have a protective effect against GI complications. Based on these observations, patients may be stratified into low-, medium-, and high-risk groups.

摘要

目的

确定心脏手术后胃肠道(GI)并发症的术前及围手术期危险因素。

设计

回顾一个包含接受心脏手术患者记录的数据库,对几个被认为与GI并发症相关的变量进行单因素分析。使用风险调整模型,术前分层用于拟合一个包含手术特征的逻辑回归模型。

地点和患者

1991年1月1日至1994年12月31日在一所大学附属医院接受心脏手术的所有患者。

主要观察指标

基于多因素分析的GI并发症发生率、术后死亡率、住院时间及GI并发症的相对风险。

结果

2.1%的患者发生了胃肠道并发症,相关死亡率为19.4%;这高于无GI并发症患者的死亡率(4.1%;P <.001)。GI并发症患者的住院时间显著更长(43天对13.4天;P <.001)。仅接受冠状动脉旁路移植术的患者中,GI并发症患者的体外循环时间显著更长(166分钟对138分钟;P =.004)。接受瓣膜置换术的患者中,体外循环时间与GI并发症无关。使用左乳内动脉移植与GI并发症发生率较低相关。

结论

心脏手术后发生GI并发症的患者死亡率更高,住院时间更长。使用左乳内动脉似乎对GI并发症有保护作用。基于这些观察结果,可将患者分为低、中、高风险组。

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