幽门螺杆菌与宿主之间的分子模拟
Molecular mimicry between Helicobacter pylori and the host.
作者信息
Appelmelk B J, Negrini R, Moran A P, Kuipers E J
机构信息
Dept of Medical Microbiology, Vrije Universiteit, Amsterdam, The Netherlands.
出版信息
Trends Microbiol. 1997 Feb;5(2):70-3. doi: 10.1016/S0966-842X(96)10084-6.
PMID:9108933
Abstract
Helicobacter pylori lipopolysaccharide (LPS) expresses Lewis x and Lewis y blood group antigens that are identical to those occurring in the human gastric mucosa. During infection, antibodies against LPS, which bind to host Lewis antigens, may be induced. These consequently recognize gastric glycoprotein targets and cause autoimmune inflammation.
摘要
幽门螺杆菌脂多糖（LPS）表达的Lewis x和Lewis y血型抗原与人类胃黏膜中存在的抗原相同。在感染过程中，可能会诱导产生针对与宿主Lewis抗原结合的LPS的抗体。这些抗体随后会识别胃糖蛋白靶点并引发自身免疫性炎症。
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