Schulze K, Dodds W J, Christensen J, Wood J D
Am J Physiol. 1977 Sep;233(3):E152-9. doi: 10.1152/ajpendo.1977.233.3.E152.
The opossum esophagus is commonly used as an animal model of the human esophagus. We used esophageal manometry in normal animals to provide basal data about normal esophageal motor functions in vivo in this species. At rest, separate and distinct high pressure zones can be recorded at the level of the lower esophageal sphincter, diaphragmatic hiatus, aortic arch, and upper esophageal sphincter. Each zone demonstrates a characteristic pattern of pressures in the radii of the coronal section and a characteristic response to swallowing. The hiatal and aortic zones can be mistaken for the esophageal sphincters. Pressures in the sphincters fall with swallowing. Peristalsis is not bolus-dependent and occurs with 98% of swallows. Pressures generated by peristalsis are greater in the middle of the esophagus than at the ends. Values for resting lower esophageal sphincter pressure and the characteristics of peristalsis were reproducible between different studies in the same animals.
负鼠食管通常被用作人类食管的动物模型。我们在正常动物中使用食管测压法来提供该物种体内正常食管运动功能的基础数据。在静息状态下，可在下食管括约肌、膈裂孔、主动脉弓和上食管括约肌水平记录到独立且不同的高压区。每个区域在冠状切面半径上都显示出特征性的压力模式以及对吞咽的特征性反应。裂孔区和主动脉区可能会被误认为是食管括约肌。括约肌压力在吞咽时下降。蠕动不依赖于食团，98%的吞咽动作都会引发蠕动。食管中部蠕动产生的压力大于两端。在对同一动物的不同研究中，静息下食管括约肌压力值和蠕动特征具有可重复性。
