Charous S J, Stricklin G P, Nanney L B, Netterville J L, Burkey B B
Department of Otolaryngology-Head and Neck Surgery, Vanderbilt University Medical Center, Nashville, Tennessee, USA.
Ann Otol Rhinol Laryngol. 1997 Apr;106(4):271-8. doi: 10.1177/000348949710600402.
Matrix metalloproteinases (MMPs) are a family of proteolytic enzymes implicated in the invasion and metastasis of many cancers. In situ hybridization techniques were used to reveal sites of expression of collagenase (MMP-1), gelatinase 72 kd (MMP-2), gelatinase 92 kd (MMP-9), and tissue inhibitor of metalloproteinase-1 (TIMP-1) in head and neck carcinomas (N = 21). Both TIMP-1 and gelatinase 72 kd were expressed in nearly all tumors, whereas the expression of collagenase and gelatinase 92 kd showed variability. Tumor-associated expression of MMPs was strongest in stromal cells near advancing margins. No differences in expression levels were detected between primary and metastatic sites. This paper reviews the literature and discusses the significance and possible implications of MMPs in head and neck squamous cell carcinoma.
基质金属蛋白酶（MMPs）是一族蛋白水解酶，与多种癌症的侵袭和转移有关。采用原位杂交技术揭示了胶原酶（MMP-1）、72kd明胶酶（MMP-2）、92kd明胶酶（MMP-9）和金属蛋白酶组织抑制剂-1（TIMP-1）在21例头颈癌中的表达部位。TIMP-1和72kd明胶酶在几乎所有肿瘤中均有表达，而胶原酶和92kd明胶酶的表达则呈现出变异性。MMPs在肿瘤相关部位的表达在进展边缘附近的基质细胞中最强。在原发部位和转移部位之间未检测到表达水平的差异。本文回顾了相关文献，并讨论了MMPs在头颈部鳞状细胞癌中的意义及可能的影响。
