Tanaka K, Hayashi K, Shingu T, Kuga Y, Okura Y, Yasunobu Y, Ohtani H, Nomura S, Kurushima H, Saeki M, Kambe M, Kajiyama G
First Department of Internal Medicine, Hiroshima University School of Medicine, Japan.
Metabolism. 1997 Apr;46(4):355-8. doi: 10.1016/s0026-0495(97)90046-9.
We determined the most effective dosage of pentaerythritol tetranicotinate (niceritrol) to reduce plasma lipoprotein(a) [Lp(a)] levels in 44 Japanese patients (16 men and 28 women; mean age, 59.2 +/- 10.8 years) with hyperlipidemia types IIa, IIb, and IV. Patients received oral niceritrol at a dosage of 750 mg (3 tablets)/d for 8 weeks, followed by 1,500 mg (6 tablets)/d for 8 weeks. Administration of niceritrol 750 mg/d for 8 weeks decreased total and low-density lipoprotein (LDL) cholesterol in patients with type IIa hyperlipidemia and decreased triglycerides in patients with type IV hyperlipidemia, but did not affect Lp(a). However, niceritrol 1,500 mg/d for 8 weeks decreased Lp(a) in patients with initial Lp(a) levels greater than 30 mg/dL in addition to decreasing total and LDL cholesterol and triglycerides. These results suggest that the effective dosage of niceritrol to reduce the serum Lp(a) concentration in Japanese hyperlipidemic patients with a high Lp(a) level (> or = 30 mg/dL) is greater than 1,500 mg/d.
我们确定了季戊四醇四烟酸酯（烟酯醇）降低44例IIa型、IIb型和IV型高脂血症日本患者（16名男性和28名女性；平均年龄59.2±10.8岁）血浆脂蛋白(a)[Lp(a)]水平的最有效剂量。患者口服烟酯醇，剂量为750毫克（3片）/天，持续8周，随后为1500毫克（6片）/天，持续8周。IIa型高脂血症患者服用750毫克/天烟酯醇8周可降低总胆固醇和低密度脂蛋白（LDL）胆固醇，IV型高脂血症患者服用后甘油三酯降低，但对Lp(a)无影响。然而，对于初始Lp(a)水平大于30毫克/分升的患者，服用1500毫克/天烟酯醇8周除了降低总胆固醇、LDL胆固醇和甘油三酯外，还降低了Lp(a)。这些结果表明，对于Lp(a)水平较高（≥30毫克/分升）的日本高脂血症患者，降低血清Lp(a)浓度的烟酯醇有效剂量大于1500毫克/天。
