Buchpiguel C A, Mathias S C, Itaya L Y, Barros N G, Portela L A, Freitas J M, Caramelli P, Carrilho P E, Bacheschi L A, Hironaka F H, Nitrini R
Department of Radiology, São Paulo University, School of Medicine, Brasil.
Arq Neuropsiquiatr. 1996 Sep;54(3):375-83. doi: 10.1590/s0004-282x1996000300003.
The aim of this study was to compare the accuracy of computed tomography (CT) and single photon emission computerized tomography (SPECT) in the diagnosis of dementia. Fifty-two patients with clinical diagnosis of dementia and 11 controls were studied. The scans were interpreted by one experienced neuroradiologist and one nuclear radiologist, both blinded to the clinical data. In the diagnosis of dementia, CT and SPECT showed equal sensitivity (82.7%) and statistically similar specificity (63.8 and 81.8%, respectively). The specificity of SPECT in diagnosing Alzheimer's disease (100%) was statistically superior to CT (69%). However, both methods showed similar sensitivity in detecting Alzheimer's disease. In conclusion, SPECT and CT showed similar accuracy in the diagnosis of dementia. The quite high specificity of SPECT in Alzheimer's disease may be useful for confirming that diagnosis, particularly for patients with presenile onset of the disease.
本研究的目的是比较计算机断层扫描（CT）和单光子发射计算机断层扫描（SPECT）在痴呆诊断中的准确性。研究了52例临床诊断为痴呆的患者和11名对照者。扫描结果由一位经验丰富的神经放射科医生和一位核放射科医生解读，两人均对临床数据不知情。在痴呆诊断中，CT和SPECT显示出相同的敏感性（82.7%），特异性在统计学上相似（分别为63.8%和81.8%）。SPECT诊断阿尔茨海默病的特异性（100%）在统计学上优于CT（69%）。然而，两种方法在检测阿尔茨海默病方面显示出相似的敏感性。总之，SPECT和CT在痴呆诊断中显示出相似的准确性。SPECT在阿尔茨海默病中相当高的特异性可能有助于确诊，特别是对于早发性疾病患者。
