淋巴细胞对草花粉抗原的反应：与放射变应原吸附试验的相关性及免疫疗法的效果
Lymphocyte response to grass pollen antigens: a correlation with radioallergosorbent test and effect of immunotherapy.
作者信息
Nagaya H, Lee S K, Reddy P M, Pascual H, Jerome D, Sadai J, Gupta S, Lauridsen J
出版信息
Ann Allergy. 1977 Oct;39(4):246-52.
The deoxyribonucleic acid (DNA) synthetic response of cultured lymphocytes to grass pollen antigens was significantly higher in 66 untreated atopic patients than in 15 non-atopic subjects (p less than 0.05). There was no correlation between the DNA synthetic response and the specific IgE antibody level as measured by radioallergosorbent test in the 81 subjects (r= 0.13; p greater than 0.2). The effect of immunotherapy on proliferative lymphocyte response and specific IgE antibody response to grass pollen antigens was evaluated prospectively in 22 atopic patients. The DNA synthetic response to grass pollen antigens was significantly reduced after immunotherapy (p less than 0.01) but the specific IgE antibody level did not change significantly.
在66名未经治疗的特应性患者中，培养的淋巴细胞对草花粉抗原的脱氧核糖核酸（DNA）合成反应显著高于15名非特应性受试者（p<0.05）。在这81名受试者中，DNA合成反应与通过放射变应原吸附试验测得的特异性IgE抗体水平之间无相关性（r=0.13；p>0.2）。前瞻性评估了免疫疗法对22名特应性患者淋巴细胞增殖反应和对草花粉抗原特异性IgE抗体反应的影响。免疫疗法后，对草花粉抗原的DNA合成反应显著降低（p<0.01），但特异性IgE抗体水平无显著变化。
Zotero 插件