Kehl L J, Fairbanks C A, Laughlin T M, Wilcox G L
Graduate Program in Neuroscience, University of Minnesota, Minneapolis, MN 55455, USA. 55455, USA.
Science. 1997 Apr 25;276(5312):586-9. doi: 10.1126/science.276.5312.586.
Spinal cord injuries result in paralysis, because when damaged neurons die they are not replaced. Neurogenesis of electrophysiologically functional neurons occurred in spinal cord cultured from postnatal rats. In these cultures, the numbers of immunocytochemically identified neurons increased over time. Additionally, neurons identified immunocytochemically or electrophysiologically incorporated bromodeoxyuridine, confirming they had differentiated from mitotic cells in vitro. These findings suggest that postnatal spinal cord retains the capacity to generate functional neurons. The presence of neuronal precursor cells in postnatal spinal cord may offer new therapeutic approaches for restoration of function to individuals with spinal cord injuries.
脊髓损伤会导致瘫痪，因为受损的神经元死亡后无法被替代。在出生后大鼠的脊髓培养物中发生了具有电生理功能的神经元的神经发生。在这些培养物中，免疫细胞化学鉴定的神经元数量随时间增加。此外，通过免疫细胞化学或电生理学鉴定的神经元掺入了溴脱氧尿苷，证实它们在体外已从有丝分裂细胞分化而来。这些发现表明，出生后的脊髓保留了产生功能性神经元的能力。出生后脊髓中神经元前体细胞的存在可能为脊髓损伤个体的功能恢复提供新的治疗方法。
