Johansen J D, Andersen T F, Veien N, Avnstorp C, Andersen K E, Menné T
Department of Dermatology, Gentofte Hospital, University of Copenhagen, Hellerup, Denmark.
Acta Derm Venereol. 1997 Mar;77(2):149-53. doi: 10.2340/0001555577149153.
The aim of the present study was to investigate the relationship between patients' own recognition of skin problems using consumer products and the results of patch testing with markers of fragrance sensitization. Eight hundred and eighty-four consecutive eczema patients, 18-69 years of age, filled in a questionnaire prior to patch testing with the European standard series. The questionnaire contained questions about skin symptoms from the use of scented and unscented products as well as skin reactions from contact with spices, flowers and citrus fruits that could indicate fragrance sensitivity. A highly significant association was found between reporting a history of visible skin symptoms from using scented products and a positive patch test to the fragrance mix, whereas no such relationship could be established to the Peru balsam in univariate or multivariate analysis. Our results suggest that the role of Peru balsam in detecting relevant fragrance contact allergy is limited, while most fragrance mix-positive patients are aware that the use of scented products may cause skin problems.
本研究的目的是调查患者使用消费品时对皮肤问题的自身认知与香料致敏标志物斑贴试验结果之间的关系。884例年龄在18至69岁之间的连续性湿疹患者，在进行欧洲标准系列斑贴试验之前填写了一份问卷。问卷包含有关使用有香味和无香味产品引起的皮肤症状以及接触香料、花卉和柑橘类水果可能表明香料过敏的皮肤反应的问题。在报告有使用有香味产品出现可见皮肤症状史与香料混合物斑贴试验呈阳性之间发现了高度显著的关联，而在单变量或多变量分析中，与秘鲁香脂未建立这种关系。我们的结果表明，秘鲁香脂在检测相关香料接触性过敏方面的作用有限，而大多数香料混合物阳性的患者意识到使用有香味产品可能会导致皮肤问题。
