Körner A, Jaremko G, Eklöf A C, Aperia A
Department of Paediatrics, Semmelweis University, Budapest, Hungary.
Diabetologia. 1997 Apr;40(4):367-73. doi: 10.1007/s001250050689.
Diabetic nephropathy tends to develop more readily in patients with a family history of hypertension and/or disturbances in sodium transport across the plasma membrane. This prompted us to study the renal effects of diabetes mellitus in a rat strain which is predisposed to develop salt-sensitive hypertension, the Dahl salt-sensitive rat. Diabetes is associated with several aberrations in the renal handling of sodium, such as elevation of tubular Na+, K+ATPase activity. This effect was more pronounced in Dahl salt-sensitive than in Dahl salt-resistant rats. Severe renal lesions, characteristic of the advanced phase of diabetic nephropathy are very rarely observed in rats with streptozotocin diabetes. However, 2 months after induction of diabetes, the Dahl salt-sensitive rats had morphological signs of advanced glomerular disease. The urinary albumin concentration was very high, but did not correlate with the blood pressure. Non-diabetic Dahl salt-sensitive rats as well as Dahl salt-resistant diabetic and non-diabetic rats had little or no signs of glomerular disease and consistently very low urinary albumin concentrations.
糖尿病肾病在有高血压家族史和/或跨质膜钠转运紊乱的患者中更容易发生。这促使我们在一种易患盐敏感性高血压的大鼠品系—— Dahl盐敏感大鼠中研究糖尿病对肾脏的影响。糖尿病与肾脏对钠的处理存在多种异常有关，例如肾小管Na + 、K + -ATP酶活性升高。这种作用在Dahl盐敏感大鼠中比在Dahl盐抵抗大鼠中更为明显。在链脲佐菌素诱导的糖尿病大鼠中，很少观察到糖尿病肾病晚期特征性的严重肾脏病变。然而，糖尿病诱导2个月后，Dahl盐敏感大鼠出现了晚期肾小球疾病的形态学迹象。尿白蛋白浓度非常高，但与血压无关。非糖尿病的Dahl盐敏感大鼠以及Dahl盐抵抗的糖尿病和非糖尿病大鼠几乎没有或没有肾小球疾病的迹象，尿白蛋白浓度一直很低。
