接受拉莫三嗪治疗的母亲及其新生儿体内拉莫三嗪的浓度。
Concentrations of lamotrigine in a mother on lamotrigine treatment and her newborn child.
作者信息
Rambeck B, Kurlemann G, Stodieck S R, May T W, Jürgens U
机构信息
Department of Biochemistry, Gesellschaft für Epilepsieforschung, Bielefeld, Germany.
出版信息
Eur J Clin Pharmacol. 1997;51(6):481-4. doi: 10.1007/s002280050234.
OBJECTIVE
To investigate the transfer of lamotrigine in pregnancy and during lactation from a mother on lamotrigine treatment to her child.
METHODS
Concentrations of lamotrigine were measured by high-pressure liquid chromatography in umbilical cord serum and in serum samples of the mother and her child as well as in the mother's milk during the first five postpartum months.
RESULTS
In the child lamotrigine serum concentrations (up to 2.8 micrograms ml-1) comparable to those usually achieved in active treatment with lamotrigine were found not only after birth, but also during lactation. A considerable amount of lamotrigine (2-5 mg per day) was excreted in breast milk. No adverse effects were seen in the child.
CONCLUSION
The transfer of lamotrigine taking place during pregnancy and lactation should not be neglected. In this case the child should be thoroughly observed for potential adverse effects.
目的
研究接受拉莫三嗪治疗的母亲在妊娠和哺乳期将拉莫三嗪传递给其孩子的情况。
方法
采用高压液相色谱法测定产后头五个月期间脐带血清、母亲及其孩子血清样本以及母乳中的拉莫三嗪浓度。
结果
在孩子体内，不仅在出生后，而且在哺乳期都发现拉莫三嗪血清浓度（高达2.8微克/毫升）与拉莫三嗪积极治疗通常达到的浓度相当。相当数量的拉莫三嗪（每天2 - 5毫克）随母乳排出。孩子未出现不良反应。
结论
妊娠和哺乳期发生的拉莫三嗪传递不容忽视。在这种情况下，应密切观察孩子是否有潜在的不良反应。
Zotero 插件