低温对在离体大鼠心房中观察到的普萘洛尔心脏效应的影响。

Influence of hypothermia on the cardiac effects of propranolol observed in isolated rat atria.

Melnikov A L, Løkebø J E, Helgesen K G, Lathrop D A

Basic Cardiac Research Laboratory, Kirkenes Hospital, Norway.

Gen Pharmacol. 1997 Jan;28(1):55-9. doi: 10.1016/s0306-3623(96)00179-6.

Abstract

The purpose was to determine if hypothermia influences cardiac responses to propranolol. 2. Rat atria were used and 11 test groups were created; 3 control groups were maintained at 35, 28 or 20 degrees C. Two additional groups, at each temperature, were exposed to 1.2 or 40 mumol/l propranolol. Developed force and effective refractory period (ERP) were measured. 3. At 35 degrees C, propranolol decreased developed force and lengthened ERP. At 28 degrees C, propranolol did not affect developed force, but ERP was lengthened. At 20 degrees C, 1.2 microM propranolol neither affected developed force or ERP, but 40 microM reduced developed force and lengthened ERP.

hypothermia reduced propranolol's usual negative inotropic effect.

摘要

目的是确定低温是否会影响心脏对普萘洛尔的反应。2. 使用大鼠心房并创建了11个测试组；3个对照组分别维持在35、28或20摄氏度。在每个温度下，另外两个组分别暴露于1.2或40微摩尔/升的普萘洛尔。测量了心肌收缩力和有效不应期（ERP）。3. 在35摄氏度时，普萘洛尔降低了心肌收缩力并延长了ERP。在28摄氏度时，普萘洛尔不影响心肌收缩力，但延长了ERP。在20摄氏度时，1.2微摩尔/升的普萘洛尔既不影响心肌收缩力也不影响ERP，但40微摩尔/升的普萘洛尔降低了心肌收缩力并延长了ERP。