文献检索，用中文搜 PubMed

Suppr 超能文献

核心技术专利：CN118964589B侵权必究

核心技术专利：CN118964589B侵权必究

Burmistrov Y M, Shuranova Z P, Artiukhina N I

Institute of Information Transmission Problems, Russian Academy of Sciences, Moscow, Russia.

Gen Pharmacol. 1997 Jan;28(1):159-66. doi: 10.1016/0306-3623(95)00067-4.

Black widow spider venom (BWSV), or crustacean-specific toxin purified from it (named latrocrustatoxin, LCT) were lethal for the crayfish. 2. Distortions in the EMG and motor activity pattern after LCT injection indicated venom effects on the crayfish nervous system. 3. In the isolated ventral nerve cord, transient activation of the "silent" interneurons and motoneurons occurred after BWSV or LCT application. 4. In the isolated nerve-muscle preparation, LCT application elicited an intense transmitter release resulting in the complete blockade of neuromuscular transmission. 5. Electron microscopic study of the nervous and muscle tissue in venom treated crayfish demonstrated certain destructive changes in the nervous cells especially in the nerve terminals. 6. The results suggest that the LCT acts as a presynaptic neurotoxin in the central and peripheral nervous system of the crayfish.

黑寡妇蜘蛛毒液（BWSV）或从其中纯化出的针对甲壳类动物的毒素（名为龙虾毒素，LCT）对小龙虾具有致死性。2. 注射LCT后肌电图和运动活动模式的扭曲表明毒液对小龙虾神经系统有影响。3. 在分离的腹神经索中，施加BWSV或LCT后，“沉默”的中间神经元和运动神经元会出现短暂激活。4. 在分离的神经-肌肉标本中，施加LCT会引发强烈的递质释放，导致神经肌肉传递完全阻断。5. 对经毒液处理的小龙虾的神经和肌肉组织进行电子显微镜研究表明，神经细胞尤其是神经末梢出现了某些破坏性变化。6. 结果表明，LCT在小龙虾的中枢和外周神经系统中充当突触前神经毒素。

Burmistrov Y M, Shuranova Z P, Artiukhina N I

Institute of Information Transmission Problems, Russian Academy of Sciences, Moscow, Russia.

Gen Pharmacol. 1997 Jan;28(1):159-66. doi: 10.1016/0306-3623(95)00067-4.

Black widow spider venom (BWSV), or crustacean-specific toxin purified from it (named latrocrustatoxin, LCT) were lethal for the crayfish. 2. Distortions in the EMG and motor activity pattern after LCT injection indicated venom effects on the crayfish nervous system. 3. In the isolated ventral nerve cord, transient activation of the "silent" interneurons and motoneurons occurred after BWSV or LCT application. 4. In the isolated nerve-muscle preparation, LCT application elicited an intense transmitter release resulting in the complete blockade of neuromuscular transmission. 5. Electron microscopic study of the nervous and muscle tissue in venom treated crayfish demonstrated certain destructive changes in the nervous cells especially in the nerve terminals. 6. The results suggest that the LCT acts as a presynaptic neurotoxin in the central and peripheral nervous system of the crayfish.

黑寡妇蜘蛛毒液（BWSV）或从其中纯化出的针对甲壳类动物的毒素（名为龙虾毒素，LCT）对小龙虾具有致死性。2. 注射LCT后肌电图和运动活动模式的扭曲表明毒液对小龙虾神经系统有影响。3. 在分离的腹神经索中，施加BWSV或LCT后，“沉默”的中间神经元和运动神经元会出现短暂激活。4. 在分离的神经-肌肉标本中，施加LCT会引发强烈的递质释放，导致神经肌肉传递完全阻断。5. 对经毒液处理的小龙虾的神经和肌肉组织进行电子显微镜研究表明，神经细胞尤其是神经末梢出现了某些破坏性变化。6. 结果表明，LCT在小龙虾的中枢和外周神经系统中充当突触前神经毒素。