Januszewicz W, Chodakowska J
Department of Hypertension and Angiology, Medical Academy, Warszawa, Poland.
Pol J Pharmacol. 1996 Jan-Feb;48(1):61-5.
The paper reviews the main lines of research pertaining to modern understanding of pathogenesis of essential hypertension. Attention is focused on the role of sympathetic activity, including the neuropeptide Y, as well as on those of atrial natriuretic peptide, endothelins and nitric oxide. The concept of endothelial dysfunction is discussed as a possible factor contributing to the development of hypertension, but also as its sequel. Finally, hyperinsulinemia and insulin resistance are viewed within a scope of interrelated factors of possible pathogenetic significance in essential hypertension. Genetic studies are singled out as the most promising line of further research.
本文综述了与现代对原发性高血压发病机制理解相关的主要研究方向。重点关注交感神经活动的作用，包括神经肽Y，以及心房利钠肽、内皮素和一氧化氮的作用。讨论了内皮功能障碍这一概念，它既是导致高血压发展的一个可能因素，也是高血压的后果。最后，在原发性高血压可能具有发病机制意义的相关因素范围内审视了高胰岛素血症和胰岛素抵抗。基因研究被视为最具前景的进一步研究方向。
