Moniwa N
Department of Obstetrics and Gynecology, Hamamatsu University School of Medicine, Shizuoka, Japan.
Pol J Pharmacol. 1996 Mar-Apr;48(2):215-20.
Suppression of the fibrinolytic activity plays an important role in the prevention of hemorrhage during pregnancy and labor. A hypofibrinolytic and hypercoagulable state may be established in the placenta during pregnancy. However, little infraction is present in the normal placenta. This evidence shows that placenta maintains the fibrinolytic activity in spite of hypercoagulable state. As there is a high amount of APC in the placenta, APC is thought to be involved in fibrinolysis of placenta. Thus, we studied the role of APC on fibrinolysis in placenta. (1) uPA activity of cell membrane reappears after incubation with uPA/PAI-1 complex and a large amount of APC by flow cytometry, (2) APC was made PAI-1/APC complex after incubation of uPA/PAI-1 complex with APC. Our results suggest that APC is the important substance for fibrinolysis in the placenta by decreasing of PAI activity.
纤维蛋白溶解活性的抑制在孕期和分娩期预防出血中起重要作用。孕期胎盘内可能会出现低纤维蛋白溶解和高凝状态。然而，正常胎盘中几乎没有梗死。这一证据表明，尽管处于高凝状态，胎盘仍保持纤维蛋白溶解活性。由于胎盘中存在大量活化蛋白C（APC），APC被认为参与了胎盘的纤维蛋白溶解过程。因此，我们研究了APC在胎盘纤维蛋白溶解中的作用。（1）通过流式细胞术检测，细胞膜的尿激酶型纤溶酶原激活物（uPA）活性在与uPA/纤溶酶原激活物抑制剂-1（PAI-1）复合物及大量APC孵育后重现；（2）uPA/PAI-1复合物与APC孵育后，APC形成了PAI-1/APC复合物。我们的结果表明，APC通过降低PAI活性，是胎盘中纤维蛋白溶解的重要物质。
