Kłoczko J, Wojtukiewicz M Z, Galar M, Tarasów E, Jaromin J, Bielawiec M
Department of Haematology, Medical Academy, Białystok, Poland.
Pol J Pharmacol. 1996 Mar-Apr;48(2):233-5.
Prothrombin activation fragment 1 + 2 (F1 + 2) and thrombin-antithrombin-III complexes (TAT) were measured in plasma of 34 patients with newly diagnosed essential hypertension. The patients with hypertension showed an increase in both F1 + 2 and TAT concentrations. The obtained results point to the intravascular thrombin generation in very early stages of essential hypertension.