Kostowski W
Department of Pharmacology and Physiology of the Nervous System, Institute of Psychiatry and Neurology, Warszawa, Poland.
Pol J Pharmacol. 1996 May-Jun;48(3):243-54.
This review discusses recent experimental findings in serotonin-3 (5-HT3) receptors and ethanol (EtOH) research. The role of these receptors in central effects of EtOH including the effects of 5-HT3 agonists and antagonists on EtOH intake, rewarding and aversive properties of EtOH and EtOH interoceptive cue is reviewed. It is now recognized that 5-HT3 receptors while involved in EtOH intake, EtOH tolerance and withdrawal and rewarding mechanisms do not play an important role in aversive effects of EtOH and EtOH discriminative stimulus. 5-HT3 receptors involved in EtOH consumption are supposedly located on dopaminergic neurons in the nucleus accumbens.
本综述讨论了血清素-3（5-HT3）受体与乙醇（EtOH）研究方面的最新实验发现。综述了这些受体在乙醇中枢效应中的作用，包括5-HT3激动剂和拮抗剂对乙醇摄入量、乙醇的奖赏和厌恶特性以及乙醇内感受性线索的影响。现在人们认识到，5-HT3受体虽然参与乙醇摄入、乙醇耐受性和戒断以及奖赏机制，但在乙醇的厌恶效应和乙醇辨别刺激中并不起重要作用。参与乙醇消耗的5-HT3受体可能位于伏隔核的多巴胺能神经元上。
