Panariti E, Xinxo A, Leksani D
Institute of Public Health, Tirana, Albania.
Dtsch Tierarztl Wochenschr. 1997 Mar;104(3):97-8.
Pyrrolizidine alkaloids (PAs) contamination of animal products, may pose a threat to human health. Among ruminants, sheep appear to be more resistant to PAs poisoning and consequently comparatively higher concentrations of the PAs into their milk might be expected. To investigate the PAs transfer into sheep's milk following multiple intakes, three lactating sheep were submitted to the administration of 14C-seneciphylline in daily amounts of 32.4 mg, for a 5 days period. The appearance of radioactivity, derived from this compound was monitored in blood and milk and was calculated as seneciphylline, Alkaloid levels in blood during the first hour following the first dose administration, were 167 ng/ml and reached a maximum of 518 ng/ml at the 5th day of multiple treatment, before falling below the detection limit at the second day of the post treatment period. The Milk levels were respectively 62.3 ng/ml at the 3rd hour following the first dose administration, reaching a maximum of 987 ng/ml at the 5th day and falling below the detection limit at the fourth day of the postreatment period. The Seneciphylline levels in liver at the end of the 5 d multiple administration period averaged at 85 ng/g corresponding to 0.22% of the daily intake.
吡咯里西啶生物碱（PAs）对动物产品的污染可能对人类健康构成威胁。在反刍动物中，绵羊似乎对PAs中毒更具抵抗力，因此可能会在其乳汁中积累相对较高浓度的PAs。为了研究多次摄入后PAs在绵羊乳汁中的转移情况，三只泌乳母羊连续5天每天摄入32.4mg的14C-千里光碱。监测血液和乳汁中该化合物产生的放射性，并以千里光碱计算。首次给药后第一小时血液中的生物碱水平为167ng/ml，多次给药第5天达到最高值518ng/ml，然后在停药期第二天降至检测限以下。乳汁中的水平在首次给药后第3小时为62.3ng/ml，在第5天达到最高值987ng/ml，并在停药期第4天降至检测限以下。在5天多次给药期结束时，肝脏中的千里光碱水平平均为85ng/g，相当于每日摄入量的0.22%。
