Some geiparvarin bioisosteres and homologues: synthesis and biological evaluation against human colon carcinoma cells (LoVo).
作者信息
Valenti P, Rampa A, Bisi A, Belluti F, Da Re P, Carrara M, Cima L
机构信息
Department of Pharmaceutical Sciences, University of Bologna, Italy.
出版信息
Anticancer Drug Des. 1997 Mar;12(2):137-44.
PMID:9113068
Abstract
Some geiparvarin bioisosteres and homologues are described. The compounds were tested on LoVo cells (human colon carcinoma cell line). The EC50 values of the synthesized compounds ranged from 35.04 microM (compound 3) to 11.88 microM (compound 4), while the EC50 value of geiparvarin 1 was 13.30 microM.
摘要
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