Nagamura S, Asai A, Kobayashi E, Gomi K, Saito H
Tokyo Research Laboratories, Kyowa Hakko Kogyo Co., Ltd., Japan.
Bioorg Med Chem. 1997 Mar;5(3):623-30. doi: 10.1016/s0968-0896(96)00276-3.
New duocarmycin SA derivatives have been synthesized and evaluated for in vitro anticellular activity against HeLa S3 cells, and in vivo antitumor activity against murine sarcoma 180 in mice. The results suggested that the N,N-dialkylcarbamoyl derivatives bearing the p-methoxy cinnamoyl group, which was prepared from duocarmycin SA, showed good in vivo antitumor activities superior to native duocarmycin SA.
已经合成了新型的多卡霉素SA衍生物，并对其针对HeLa S3细胞的体外抗细胞活性以及针对小鼠肉瘤180的体内抗肿瘤活性进行了评估。结果表明，由多卡霉素SA制备的带有对甲氧基肉桂酰基的N，N-二烷基氨基甲酰基衍生物显示出优于天然多卡霉素SA的良好体内抗肿瘤活性。
