Biernat J, Grajeta H
Wroclaw University of Medicine, Department of Food Science and Nutrition, Poland.
Nahrung. 1997 Feb;41(1):46-9. doi: 10.1002/food.19970410112.
The effect on Oenothera paradoxa oil on blood serum and liver lipids metabolism in rats fed a semisynthetic high-fat cholesterol enriched diets was investigated. The source of fats was sunflower oil or lard in 15% quantities and the source of protein was soybean protein isolate in 27% quantity. The diets were enriched with 0.5% cholesterol. This dietary experiment was carried on for 8 weeks. For the first 4 weeks rats were fed standard diet and for the next 4 weeks Oe. paradoxa oil (300 mg/day/rat) was additionally given by stomach-tube. At the end of experiment the contents of total cholesterol, HDL-cholesterol, triglycerides and free fatty acids in blood serum as well as cholesterol and triglycerides level in liver were determined. It was found that the addition of cholesterol to the diet decreased the hypocholesterolemic and hypotriglyceridemic effects of Oe. paradoxa oil both in blood serum and liver. It have not had any significant effect on the free fatty acid concentration in blood serum decrease by Oe. paradoxa oil intake.
研究了月见草油对喂食半合成高脂高胆固醇饮食的大鼠血清和肝脏脂质代谢的影响。脂肪来源为15%的葵花籽油或猪油，蛋白质来源为27%的大豆分离蛋白。饲料中添加0.5%胆固醇。该饮食实验持续8周。前4周大鼠喂食标准饮食，接下来4周通过胃管额外给予月见草油（300毫克/天/只大鼠）。实验结束时测定血清中总胆固醇、高密度脂蛋白胆固醇、甘油三酯和游离脂肪酸的含量以及肝脏中胆固醇和甘油三酯的水平。发现饮食中添加胆固醇会降低月见草油在血清和肝脏中的降胆固醇和降甘油三酯作用。月见草油摄入导致的血清游离脂肪酸浓度降低方面，胆固醇添加没有任何显著影响。
