Fukushima M, Akiba S, Nakano M
Department of Bioresource Chemistry, Obihiro University of Agriculture and Veterinary Medicine, Hokkaido, Japan.
Lipids. 1996 Apr;31(4):415-9. doi: 10.1007/BF02522928.
The hypocholesterolemic efficacies of various polyunsaturated fatty acids were compared in rats given cholesterol-enriched diets. Oenothera biennis Linn oil (OBLO, linoleic + gamma-linolenic), sunflower oil (linoleic), palm oil (PLO, oleic + linoleic), soybean oil (linoleic + alpha-linolenic), high-oleic safflower oil (oleic + linoleic), or mixed oil (linoleic + alpha-linolenic) was added to the diet at 200 g/kg (20% groups). OBLO was also added at 100 g/kg diet (10% group). The serum total and very low density lipoprotein + intermediate lipoprotein + low density lipoprotein cholesterol concentrations of the 10 and 20% OBLO groups were consistently lower than those in the other groups. The liver cholesterol concentration in the PLO group was lower in all groups. The liver cholesterol concentrations in the 10 and 20% OBLO groups were also lower than in the other groups. There were no significant differences in the fecal neutral sterol and bile acid extraction among groups.
在给予富含胆固醇饮食的大鼠中比较了各种多不饱和脂肪酸的降胆固醇功效。将月见草油（OBLO，亚油酸+γ-亚麻酸）、向日葵油（亚油酸）、棕榈油（PLO，油酸+亚油酸）、大豆油（亚油酸+α-亚麻酸）、高油酸红花油（油酸+亚油酸）或混合油（亚油酸+α-亚麻酸）以200 g/kg的比例添加到饮食中（20%组）。OBLO也以100 g/kg的饮食比例添加（10%组）。10%和20% OBLO组的血清总胆固醇以及极低密度脂蛋白+中间密度脂蛋白+低密度脂蛋白胆固醇浓度始终低于其他组。PLO组的肝脏胆固醇浓度在所有组中最低。10%和20% OBLO组的肝脏胆固醇浓度也低于其他组。各组之间粪便中性固醇和胆汁酸提取量无显著差异。
