Mahfouz A E, Hamm B
Cairo University Hospital, Cairo, Egypt.
Magn Reson Imaging Clin N Am. 1997 May;5(2):223-40.
Contrast agents are needed for improvement of lesion detection and lesion characterization on hepatic MR imaging. According to their biodistribution, contrast agents are classified into extracellular, hepatocyte-targeted, macrophage-monocytic phagocytic system(MPPS)-targeted, and blood-pool contrast agents. Dynamic MR imaging of the liver enhanced with extracellular gadolinium chelates improves lesion characterization. Hepatocyte-targeted and MPPS-targeted contrast agents improve lesion detection. Hepatocyte-targeted contrast agents that have an initial extracellular distribution phase and blood-pool contrast agents offer a potential for improvement of both detection and characterization of focal hepatic lesions.
在肝脏磁共振成像中，需要使用对比剂来提高病变的检测和特征描述能力。根据其生物分布，对比剂可分为细胞外对比剂、肝细胞靶向对比剂、巨噬细胞-单核吞噬细胞系统（MPPS）靶向对比剂和血池对比剂。使用细胞外钆螯合物增强的肝脏动态磁共振成像可改善病变特征描述。肝细胞靶向对比剂和MPPS靶向对比剂可提高病变检测能力。具有初始细胞外分布阶段的肝细胞靶向对比剂和血池对比剂为改善局灶性肝病变的检测和特征描述提供了可能。
