Adams H P, Leira E C
Division of Cerebrovascular Diseases, Department of Neurology, University of Iowa College of Medicine, Iowa City, Iowa 52242, USA.
Neurosurg Clin N Am. 1997 Apr;8(2):207-17.
Although antiplatelet and anticoagulant drugs are of proven usefulness in the prevention of stroke among high-risk persons, their value in improving outcome after acute ischemic stroke has not been established. Potentially effective drugs include heparin, low molecular weight heparins and heparinoids, aspirin, and the new glycoprotein IIb/IIIa platelet receptor antagonists. Clinical trials are testing these drugs, and the role of emergent administration of anticoagulant or antiplatelet drugs in the acute treatment of persons with ischemic stroke should be clarified in the near future.
尽管抗血小板药物和抗凝药物在预防高危人群中风方面已被证明是有效的，但其在改善急性缺血性中风后预后方面的价值尚未确定。潜在有效的药物包括肝素、低分子量肝素和类肝素、阿司匹林以及新型糖蛋白IIb/IIIa血小板受体拮抗剂。临床试验正在对这些药物进行测试，抗凝或抗血小板药物在缺血性中风患者急性治疗中的紧急应用作用应在不久的将来得以明确。
