截肢糖尿病患者动脉、储存脂肪和血清中甘油三酯的脂肪酸组成。

The fatty acid composition of triglycerides in arteries, depot fat and serum of amputated diabetics.

作者信息

Singer P, Gnauck G, Honigmann G, Schliack V, Laeuter J

出版信息

Atherosclerosis. 1977 Sep;28(1):87-92. doi: 10.1016/0021-9150(77)90202-7.

Abstract

The triglyceride fatty acid pattern (TFAP) in arterial wall, adipose tissue and serum in vivo has been estimated in amputated diabetic subjects by gas-liquid chromatography simultaneously. Besides, in some probands the fatty acid pattern of cholesterol esters of vessel walls has been obtained. In arterial wall the percental content of lauric, myristic, myristoleic, palmitoleic, stearic, oleic and linolenic acid was high and that of palmitic and linoleic acid was low, when compared to serum, whereas eicosatrienoic, arachidonic and eicosapentaenoic acid were of similar magnitude. In comparison to adipose tissue myristic, palmitic and nervonic acid were decreased and eicosatrienoic, arachidonic and eicosapentaenoic acid were increased in arterial wall. In view of the results the speculation is obvious that certain fatty acids have distinct metabolic positions in several tissues, such as depot fatty acids and precursors of prostaglandins, for example.

摘要

通过气液色谱法同时对截肢的糖尿病患者体内动脉壁、脂肪组织和血清中的甘油三酯脂肪酸模式（TFAP）进行了评估。此外，在一些受试者中还获得了血管壁胆固醇酯的脂肪酸模式。与血清相比，动脉壁中月桂酸、肉豆蔻酸、肉豆蔻油酸、棕榈油酸、硬脂酸、油酸和亚麻酸的百分比含量较高，而棕榈酸和亚油酸的含量较低，而二十碳三烯酸、花生四烯酸和二十碳五烯酸的含量相似。与脂肪组织相比，动脉壁中肉豆蔻酸、棕榈酸和神经酸减少，而二十碳三烯酸、花生四烯酸和二十碳五烯酸增加。鉴于这些结果，很明显可以推测某些脂肪酸在几种组织中具有独特的代谢地位，例如储存脂肪酸和前列腺素的前体。