Calder P C, Harvey D J, Pond C M, Newsholme E A
Department of Biochemistry, University of Oxford, United Kingdom.
Lipids. 1992 Sep;27(9):716-20. doi: 10.1007/BF02536031.
The fatty acid composition of triacylglycerols from fifteen distinct adipose depots taken from each of seven adult male human subjects was compared. Oleic, palmitic, linoleic, stearic, myristic, palmitoleic and vaccenic acids accounted for more than 90% of the triacylglycerol fatty acids in all sites from all subjects; a number of other fatty acids were also identified and quantified. There were large differences in the average fatty acid composition between individual subjects. There were no site-specific differences in the proportions of myristic (3.8-4.7% of triacylglycerol fatty acids), palmitic (23-29%), linoleic (6.7-9.8%) or vaccenic (4.1-4.7%) acids or in the proportions of any of the less abundant fatty acids. There were some significant site-specific differences in the proportions of palmitoleic, oleic and stearic acids. The calf depot contained more palmitoleic acid (6.41 +/- 1.09%) than the trapezius (3.12 +/- 0.55%), perirenal (3.59 +/- 0.50%) and mesenteric (3.70 +/- 0.43%) depots, more oleic acid (42.13 +/- 1.27%) than the trapezius (36.03 +/- 2.18%), perirenal (36.50 +/- 1.56%) and breast (37.13 +/- 1.55%) depots and less stearic acid (5.18 +/- 0.89%) than the trapezius (8.57 +/- 0.97%), perirenal (8.49 +/- 0.75%), mesenteric (7.87 +/- 0.42%), breast (8.02 +/- 0.75%) and clavicular (8.34 +/- 0.78%) depots. The buttock depot contained less stearic acid (6.06 +/- 0.65%) than the perirenal, mesenteric and clavicular depots, while the anterior thigh depot contained less stearic acid (6.07 +/- 0.70%) than the perirenal depot. These findings indicate that, while most human adipose depots differ little in fatty acid composition, some sites, in particular the calf, perirenal, trapezius and mesenteric depots, have site-specific properties.
对取自7名成年男性受试者每人的15个不同脂肪储存部位的三酰甘油的脂肪酸组成进行了比较。油酸、棕榈酸、亚油酸、硬脂酸、肉豆蔻酸、棕榈油酸和反式vaccenic酸占所有受试者所有部位三酰甘油脂肪酸的90%以上；还鉴定并定量了一些其他脂肪酸。个体受试者之间的平均脂肪酸组成存在很大差异。肉豆蔻酸（占三酰甘油脂肪酸的3.8 - 4.7%）、棕榈酸（23 - 29%）、亚油酸（6.7 - 9.8%）或反式vaccenic酸（4.1 - 4.7%）的比例以及任何含量较少的脂肪酸的比例均不存在部位特异性差异。棕榈油酸、油酸和硬脂酸的比例存在一些显著的部位特异性差异。小腿脂肪储存部位所含棕榈油酸（6.41±1.09%）比斜方肌（3.12±0.55%）、肾周（3.59±0.50%）和肠系膜（3.70±0.43%）脂肪储存部位多，所含油酸（42.13±1.27%）比斜方肌（36.03±2.18%）、肾周（36.50±1.56%）和乳房（37.13±1.55%）脂肪储存部位多，所含硬脂酸（5.18±0.89%）比斜方肌（8.57±0.97%）、肾周（8.49±0.75%）、肠系膜（7.87±0.42%）、乳房（8.02±0.75%）和锁骨下（8.34±0.78%）脂肪储存部位少。臀部脂肪储存部位所含硬脂酸（6.06±0.65%）比肾周、肠系膜和锁骨下脂肪储存部位少，而大腿前侧脂肪储存部位所含硬脂酸（6.07±0.70%）比肾周脂肪储存部位少。这些发现表明，虽然大多数人体脂肪储存部位的脂肪酸组成差异不大，但一些部位，特别是小腿、肾周、斜方肌和肠系膜脂肪储存部位，具有部位特异性特征。
