Sapru R P, Chakravarti R N, Moza A K, Kanta A, Kaur U
Atherosclerosis. 1977 Oct;28(2):171-9. doi: 10.1016/0021-9150(77)90154-x.
Atherosclerosis was produced by induced alimentary hyperlipaemia in four groups of rabbits. Animals of groups II and III received cholesterol feeds daily for 2 months while in groups IV and V this was followed by another 3 months of intermittent feeding. Group I comprised normal control rabbits. Selective fibrinogen depletion was produced in groups III and V with Arvin so as to maintain the plasma fibrinogen around 100 mg/dl over the last 2 months of cholesterol feeding. Serum lipids, blood coagulation and euglobulin clot lysis as well as the post mortem histopathology of aorta, heart, kidneys, liver and lungs did not reveal any significant differences between corresponding groups of hyperlipaemic animals treated with (groups III and V) or without (groups II and IV) Arvin. It appears that fibrinogen or fibrin incorporation does not play a significant role in the pathogenesis of atherosclerotic lesions induced in rabbits by cholesterol feeding.
通过诱导四组家兔出现饮食性高脂血症来引发动脉粥样硬化。第二组和第三组动物每天接受胆固醇饲料喂养，持续2个月，而第四组和第五组在此之后再进行3个月的间歇性喂养。第一组包括正常对照家兔。在第三组和第五组中使用阿维菌素造成选择性纤维蛋白原耗竭，以便在胆固醇喂养的最后2个月将血浆纤维蛋白原维持在100mg/dl左右。血清脂质、血液凝固、优球蛋白凝块溶解以及主动脉、心脏、肾脏、肝脏和肺脏的尸检组织病理学结果显示，接受（第三组和第五组）或未接受（第二组和第四组）阿维菌素治疗的相应高脂血症动物组之间没有任何显著差异。看来纤维蛋白原或纤维蛋白的掺入在胆固醇喂养诱导的家兔动脉粥样硬化病变发病机制中不起重要作用。
