Ripley D, Weinerman B H
Vancouver Island Cancer Centre, British Columbia Cancer Agency, British Columbia.
Can J Gastroenterol. 1997 Jan-Feb;11(1):65-8. doi: 10.1155/1997/901217.
Some data suggest that there is an increased incidence of second malignancies associated with small bowel adenocarcinomas, but this has not been reviewed in the context of a tumour registry.
To review tumour registries based on population statistics to determine whether there is an increased incidence of second malignancies associated with small bowel adenocarcinomas.
The authors reviewed the tumour registries of two Canadian provinces (British Columbia and Manitoba) for small bowel adenocarcinoma to determine whether an increase in associated malignancies existed compared with those expected in the respective populations.
A greater than eightfold increase in second malignancies was associated with small bowel carcinoma. The majority (73%) occurred before the diagnosis of the small bowel malignancy. Twenty-nine per cent were associated with cancers of the colon, rectum or both.
There is an increased association of malignancy and the diagnosis of small bowel cancer. Generally, small bowel cancer is the second malignancy to be diagnosed, and the diagnosis is most often made in the elderly. Does this represent a syndrome related to an unstable gene (or genes) or a lack of repair, which makes individuals susceptible to this malignancy as they age?
一些数据表明，与小肠腺癌相关的第二原发性恶性肿瘤的发病率有所增加，但尚未在肿瘤登记的背景下对此进行综述。
基于人群统计数据对肿瘤登记进行综述，以确定与小肠腺癌相关的第二原发性恶性肿瘤的发病率是否增加。
作者查阅了加拿大两个省（不列颠哥伦比亚省和马尼托巴省）的肿瘤登记资料，以了解小肠腺癌情况，确定与之相关的恶性肿瘤发病率是否高于各自人群中的预期发病率。
与小肠癌相关的第二原发性恶性肿瘤增加了八倍多。大多数（73%）发生在小肠恶性肿瘤诊断之前。29%与结肠癌、直肠癌或两者的癌症有关。
恶性肿瘤与小肠癌诊断之间的关联增加。一般来说，小肠癌是第二个被诊断出的恶性肿瘤，且诊断大多在老年人中进行。这是否代表一种与不稳定基因（一个或多个）或缺乏修复相关的综合征，使得个体随着年龄增长易患这种恶性肿瘤？
