乳腺癌和卵巢癌易感性的倾向性检测。
Predisposition testing for breast and ovarian cancer susceptibility.
作者信息
Calzone K A
机构信息
Cancer Risk Evaluation Program, University of Pennsylvania Cancer Center, Philadelphia 19104, USA.
出版信息
Semin Oncol Nurs. 1997 May;13(2):82-90. doi: 10.1016/s0749-2081(97)80004-6.
OBJECTIVES
To provide an overview of breast cancer predisposition syndromes and the breast and Ovarian cancer susceptibility genes identified to date. To describe the clinical implications of genetic testing for breast and ovarian cancer susceptibility.
DATA SOURCES
Published research and educational manuscripts, books, conference proceedings, and personal experiences.
CONCLUSION
Nurses must become knowledgeable of predisposition genetic testing for inherited breast cancer risk including: understanding of the gene being analyzed and associated cancer risks, indications for testing, the limitations of the test, the management options for mutation carriers, risks and benefits of testing, and the long-term psychosocial sequelae.
IMPLICATIONS FOR NURSING PRACTICE
Predisposition testing for alterations in breast cancer susceptibility genes is rapidly moving into the general oncology and primary care community where nurses will play a major role in the provision of genetic services. The role of nursing in cancer genetics includes practice and education, nursing research, and policy initiatives.
目标
概述乳腺癌易感综合征以及迄今已鉴定出的乳腺癌和卵巢癌易感基因。描述乳腺癌和卵巢癌易感性基因检测的临床意义。
数据来源
已发表的研究和教育手稿、书籍、会议论文集以及个人经验。
结论
护士必须了解遗传性乳腺癌风险的易感基因检测，包括：了解所分析的基因及相关癌症风险、检测指征、检测局限性、突变携带者的管理选择、检测的风险和益处，以及长期的心理社会后果。
对护理实践的启示
乳腺癌易感基因改变的易感检测正迅速进入普通肿瘤学和初级保健领域，护士将在提供基因服务方面发挥主要作用。护理在癌症遗传学中的作用包括实践与教育、护理研究以及政策倡议。
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