Kim N S, Im S, Kim S C
Department of Dermatology, Ajou University School of Medicine, Suwon, Korea.
J Dermatol. 1997 Mar;24(3):161-4. doi: 10.1111/j.1346-8138.1997.tb02764.x.
We report electron microscopic findings from both hyperchromic and achromic macules of dyschromatosis universalis hereditaria (DUH). The keratinocytes of the hyperchromic macules contained numerous, fully melanized melanosomes; almost all of them were aggregated to form the melanosome complex. In contrast, the melanosomes were absent from both keratinocytes and melanocytes of achromic macules, even though intact melanocytes were found. Our results suggest that DUH may be a disorder of melanosome production and distribution in epidermal melanin units rather than a a disorder of melanocyte number.
我们报告了泛发性遗传性色素异常症（DUH）的深色斑和浅色斑的电子显微镜检查结果。深色斑的角质形成细胞含有大量完全黑素化的黑素小体；几乎所有黑素小体都聚集形成黑素小体复合体。相比之下，浅色斑的角质形成细胞和黑素细胞中均无黑素小体，尽管发现了完整的黑素细胞。我们的结果表明，DUH可能是表皮黑素单位中黑素小体产生和分布的紊乱，而非黑素细胞数量的紊乱。
