Betti R, Cerri A, Gualandri L, Moneghini L, Crosti C
Clinica Dermatologica IV, Università degli Studi di Milano, Ospedale S. Paolo, Italy.
J Dermatol. 1997 Mar;24(3):198-201. doi: 10.1111/j.1346-8138.1997.tb02772.x.
A 71-year-old woman presented with multiple, flesh-colored, papular lesions on the left dorsal side of the hand which had erupted 5 years earlier. No cafè-au-lait spots, freckles, or Lisch nodules were detected. Family history did not disclose neurofibromas or abnormal pigmentation. Two biopsy specimens of the lesions showed circumscribed, non-encapsulated neurofibromas. Segmental neurofibromatosis is characterized by the unilateral, segmental appearance of neurofibromas and/or cafè-au-lait spots in the absence of genetic transmission. The authors discuss the significance of localized multiple cutaneous neurofibromas in the absence of family history and suggest the possibility of a cutaneous hamartoma.
一名71岁女性，手部左侧背侧出现多个肤色丘疹性皮损，这些皮损于5年前出现。未检测到咖啡斑、雀斑或Lisch结节。家族史中未发现神经纤维瘤或色素沉着异常。对这些皮损进行的两次活检标本显示为界限清楚、无包膜的神经纤维瘤。节段性神经纤维瘤病的特征是在无遗传传递的情况下，神经纤维瘤和/或咖啡斑呈单侧、节段性出现。作者讨论了在无家族史的情况下局限性多发性皮肤神经纤维瘤的意义，并提出了皮肤错构瘤的可能性。
