Frölich J C
Hannover Medical School, Institute of Clinical Pharmacology, Germany.
Trends Pharmacol Sci. 1997 Jan;18(1):30-4. doi: 10.1016/s0165-6147(96)01017-6.
Non-steroidal anti-inflammatory drugs (NSAIDs) are, as a group, the most frequently consumed drugs worldwide. They also cause the most, and often dangerous, side-effects reported to the US Food and Drug Administration, the majority of which are owing to damage of the gastrointestinal tract and kidneys. This explains the continuous interest of pharmacologists, clinical pharmacologists and pharmacoepidemiologists in this group of drugs. Based on an increasing body of data, J. Frölich proposes a simple alternative to the usual chemical classification of NSAIDs, allowing one to predict a drug's major effects according to its relative inhibition of the constitutive and inducible cyclooxygenase isoenzymes.
非甾体抗炎药（NSAIDs）作为一个药物类别，是全球使用最为频繁的药物。它们也是向美国食品药品监督管理局报告的副作用最多且往往较为危险的药物，其中大多数副作用是由胃肠道和肾脏损伤引起的。这就解释了药理学家、临床药理学家和药物流行病学家对这类药物一直保持关注的原因。基于越来越多的数据，J. 弗罗利希提出了一种不同于常规NSAIDs化学分类的简单方法，能够根据药物对组成型和诱导型环氧化酶同工酶的相对抑制作用来预测其主要作用。
